Industrial Pharmacy I
Unit 1 Notes
Preformulation Studies : Introduction to preformulation, goals and objectives, study of physicochemical characteristics of drug substances.
a. Physical properties : Physical form (crystal & amorphous), particle size, shape, flow properties, solubility profile (pKa, pH, partition coefficient), polymorphism
b. Chemical Properties : Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and parenteral dosage forms and its impact on stability of dosage forms.