Pharmacological Screening Methods
Unit 2 Notes
Preclinical screening models
a. Introduction : Dose selection, calculation and conversions,
preparation of drug solution/suspensions, grouping of animals and
importance of sham negative and positive control groups.
Rationale for selection of animal species and sex for the study.
b. Study of screening animal models for
Diuretics, nootropics, anti-Parkinson’s, antiasthmatics,
Preclinical screening models : for CNS activity- analgesic,
antipyretic, anti-inflammatory, general anaesthetics, sedative and
hypnotics, antipsychotic, antidepressant, antiepileptic,
anti parkinsonism, alzheimer’s disease