Medicinal Chemistry I
Unit 5 Notes
Drugs acting on Central Nervous System
General anesthetics :
Inhalation anesthetics : Halothane, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.
Ultra short acting barbitutrates : Methohexital sodium, Thiamylal
sodium, Thiopental sodium.
Dissociative anesthetics : Ketamine hydrochloride.*
Narcotic and non-narcotic analgesics
Morphine and related drugs : SAR of Morphine analogues, Morphine
sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride,
Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate, Methadone hydrochloride, Propoxyphene hydrochloride, Pentazocine,
Levorphanol tartarate.
Narcotic antagonists : Nalorphine hydrochloride, Levallorphan tartarate,
Naloxone hydrochloride.
Anti-inflammatory agents : Sodium salicylate, Aspirin, Mefenamic acid, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen, Naproxen, Piroxicam, Phenacetin, Acetaminophen,
Antipyrine, Phenylbutazone