Medicinal Chemistry I
Unit 4 Notes
Drugs acting on Central Nervous System
A. Sedatives and Hypnotics :
Benzodiazepines : SAR of Benzodiazepines, Chlordiazepoxide, Diazepam, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem
Barbiturtes : SAR of barbiturates, Barbital, Phenobarbital, Mephobarbital,
Amobarbital, Butabarbital, Pentobarbital, Secobarbital
Miscelleneous :
Amides & imides: Glutethmide.
Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.
Aldehyde & their derivatives: Triclofos sodium, Paraldehyde
B. Antipsychotics
Phenothiazeines : SAR of Phenothiazeines- Promazine hydrochloride,
Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine
hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate,
Trifluoperazine hydrochloride.
Ring Analogues of Phenothiazeines : Chlorprothixene, Thiothixene,
Loxapine succinate, Clozapine.
Fluro buterophenones : Haloperidol, Droperidol, Risperidone.
Beta amino ketones : Molindone hydrochloride.
Benzamides : Sulpieride
C. Anticonvulsants : SAR of Anticonvulsants, mechanism of anticonvulsant action
Barbiturates : Phenobarbitone, Methabarbital.
Hydantoins : Phenytoin, Mephenytoin, Ethotoin
Oxazolidine diones : Trimethadione, Paramethadione
Succinimides : Phensuximide, Methsuximide, Ethosuximide
Urea and monoacylureas : Phenacemide, Carbamazepine*
Benzodiazepines : Clonazepam
Miscellaneous : Primidone, Valproic acid , Gabapentin, Felbamate