Medicinal Chemistry I
Unit 3 Notes
Cholinergic neurotransmitters :
Biosynthesis and catabolism of acetylcholine.
Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.
Parasympathomimetic agents : SAR of Parasympathomimetic agents
Direct acting agents : Acetylcholine, Carbachol, Bethanechol, Methacholine, Pilocarpine.
Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine, Pyridostigmine, Edrophonium chloride,
Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.
Cholinesterase reactivator : Pralidoxime chloride.
Cholinergic Blocking agents : SAR of cholinolytic agents
Solanaceous alkaloids and analogues : Atropine sulphate, Hyoscyamine
sulphate, Scopolamine hydrobromide, Homatropine hydrobromide,
Ipratropium bromide.
Synthetic cholinergic blocking agents : Tropicamide, Cyclopentolate hydrochloride, Clidinium Glycopyrrolate, bromide, Dicyclomine Methantheline bromide, hydrochloride, Propantheline bromide,
Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride,
Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide,
Ethopropazine hydrochloride.